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Prevention of allograft rejection by in vitro generated tolerogenic dendritic cells

✍ Scribed by Thomas E. Ichim; Robert Zhong; Wei-Ping Min

Book ID
117676368
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
843 KB
Volume
11
Category
Article
ISSN
0966-3274

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## Abstract Dendritic cells (DCs) not only induce but also modulate T cell activation. 1,25‐dihydroxyvitamin D~3~ [1,25(OH)~2~D~3~] induces DCs with a tolerogenic phenotype, characterized by decreased expression of CD40, CD80, and CD86 costimulatory molecules, low IL‐12 and enhanced IL‐10 secretion