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Prevention of Acute and Chronic Allograft Rejection by Combinations of Tolerogenic Dendritic Cells

✍ Scribed by Y. L. Huang; Y. Z. Wang; J. B. Chen; F. Wang; X. P. Kang; J. J. Xia; T. S. Lan; B. Y. Xie; H. Ekberg; X. M. Wang; Z. Q. Qi

Book ID
110861997
Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
670 KB
Volume
73
Category
Article
ISSN
0300-9475

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## Abstract Dendritic cells (DCs) not only induce but also modulate T cell activation. 1,25‐dihydroxyvitamin D~3~ [1,25(OH)~2~D~3~] induces DCs with a tolerogenic phenotype, characterized by decreased expression of CD40, CD80, and CD86 costimulatory molecules, low IL‐12 and enhanced IL‐10 secretion