Prevalence ofTP53germ line mutations in young Pakistani breast cancer patients
β Scribed by Muhammad U. Rashid, Sidra Gull, Kashif Asghar, Noor Muhammad, Asim Amin, Ute Hamann
- Book ID
- 113065634
- Publisher
- Springer Netherlands
- Year
- 2012
- Tongue
- English
- Weight
- 192 KB
- Volume
- 11
- Category
- Article
- ISSN
- 1389-9600
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The cause of Li-Fraumeni syndrome, a rare group syndrome of familial cancers, has recently been identified. Patients with this inherited condition are highly susceptible to specific neoplasms, including early-onset breast cancers. The available evidence links Li-Fraumeni syndrome to inherited mutati
## Abstract Among Asian countries, Pakistan has the highest rates of breast and ovarian cancer. To assess the contribution of the __BRCA1__ and __BRCA2__ germ line mutations to these high rates, we conducted the first study of 176 Pakistani breast and ovarian cancer patients, selected on family his