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Prevalence of the factor V Leiden mutation in children and neonates with thromboembolic disease

✍ Scribed by J.Nathan Hagstrom; Johannes Walter; Rachel Bluebond-Langner; Joan C. Amatniek; Catherine S. Manno; Katherine A. High

Book ID: 117166082
Publisher: Elsevier Science
Year: 1998
Tongue: English
Weight: 40 KB
Volume: 133
Category: Article
ISSN: 1097-6833
DOI: 10.1016/s0022-3476(98)70150-7

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Resistance to activated protein C (APC) is the most common inherited risk factor for venous thrombosis. Most cases of APC resistance are caused by the point mutation nt 1691 G-A in factor V gene, referred to as factor V Leiden mutation. As initially shown in a Dutch population, this mutation has a c