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Prevalence of Hepatitis C Virus Infection in Hemodialysis Patients: A Longitudinal Study Comparing the Results of RNA and Antibody Assays

✍ Scribed by Tak Mao Chan; Anna Suk Fong Lok; Ignatius Kum Po Cheng; Rachel Tzun Chan

Publisher: John Wiley and Sons
Year: 1993
Tongue: English
Weight: 465 KB
Volume: 17
Category: Article
ISSN: 0270-9139
DOI: 10.1002/hep.1840170103

No coin nor oath required. For personal study only.

✦ Synopsis

We longitudinally studied 51 patients from two hemodialysis centers to determine the prevalence of hepatitis C virus infection in hemodialysis patients. Serum samples were tested for antibody to HCV by first-and second-generation enzyme immunoassays and for hepatitis C virus RNA by nested polymerase chain reaction assay. Antibody to hepatitis C virus was detected in the initial serum samples by firstgeneration enzyme immunoassay and secondgeneration enzyme immunoassay in 6 (11.8%) and 11 (2 1.6%) patients, respectively. First-generation enzyme immunoassay had a false-positive rate of 33.3% and a false-negative rate of 63.6%. Hepatitis C virus

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