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A high prevalence of antibody to the hepatitis C virus in patients with hepatocellular carcinoma in Japan

✍ Scribed by Kusuya Nishioka; Junnosuke Watanabe; Seiichi Furuta; Eiji Tanaka; Shiro Iino; Hiroshi Suzuki; Takao Tsuji; Michitami Yano; George Kuo; Qui-Lim Choo; Michael Houghton; Toshitsugu Oda

Publisher
John Wiley and Sons
Year
1991
Tongue
English
Weight
423 KB
Volume
67
Category
Article
ISSN
0008-543X

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✦ Synopsis

In Japan, hepatocellular carcinoma (HCC) is one of the most prevalent cancers, with a reported fatality rate showing a consistent and significant increase in the last decade. At most, only 25% of HCC cases are positive for the hepatitis B surface antigen (HBsAg). To investigate a potential role for hepatitis C virus (HCV) in the development of HCC, sera from 105 HBsAg-negative HCC patients were collected from five districts of Japan and assayed for antibody to HCV antigen (HCVAb). A large number of these patients (76.2%) were found to be positive for the HCVAb in comparison with the reported prevalence in sera from blood donors (1.1%). A history of blood transfusion was found in 39.6% of the cases positive for HCVAb, which was significantly different to the lower rate (4.7%) observed in HCC patients who were both positive for HBsAg and negative for HCVAb (P < 0.001).

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