Maturity onset diabetes of the young (MODY) is a genetically heterogeneous form of type 2 diabetes that is characterized by autosomal dominant inheritance, onset in early adulthood and a primary defect in insulin secretion. Mutations in at least six genes have been shown to underlie MODY, including
Prevalence, Characteristics and Clinical Diagnosis of Maturity Onset Diabetes of the Young Due to Mutations in HNF1A, HNF4A, and Glucokinase: Results From the SEARCH for Diabetes in Youth
β Scribed by Pihoker, Catherine; Gilliam, Lisa K.; Ellard, Sian; Dabelea, Dana; Davis, Cralen; Dolan, Lawrence M.; Greenbaum, Carla J.; Imperatore, Giuseppina; Lawrence, Jean M.; Marcovina, Santica M.; Mayer-Davis, Elizabeth; Rodriguez, Beatriz L.; Steck, Andrea K.; Williams, Desmond E.; Hattersley, Andrew T.
- Book ID
- 121396049
- Publisher
- Endocrine Society
- Year
- 2013
- Tongue
- English
- Weight
- 339 KB
- Volume
- 98
- Category
- Article
- ISSN
- 0021-972X
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Maturity-onset diabetes of the young (MODY) is a subtype of early-onset diabetes mellitus which is characterized by autosomal dominant inheritance. Several genes are known to induce MODY : HNF4A/MODY1, GCK/MODY2, TCF1/MODY3, IPF1/MODY4, TCF2/MODY5 and NEUROD1/MODY6. We studied a Swiss family with 13