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Pretranslational and Posttranslational Regulation of Rat Hepatic CYPs 3A2 and 2E1 by Disulfiram

✍ Scribed by Robert Martini; Magnus Ingelman-Sundberg; Michael Murray

Book ID
119407411
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
533 KB
Volume
54
Category
Article
ISSN
0006-2952

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## Abstract We report a comprehensive examination of rat hepatic CYP1A2 and CYP2E1 ontogeny. We compare the data to human data to determine the rat's capacity as a model to identify CYP‐mediated mechanisms underlying age‐dependent differences in susceptibility to toxicity. We evaluated CYP expressi