Hepatic CYP1A, 2B, 2C, 2E and 3A regulation by methoxychlor in male and female rats
✍ Scribed by Luis F. Oropeza-Hernández; Ricardo López-Romero; Arnulfo Albores
- Book ID
- 119537704
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- English
- Weight
- 385 KB
- Volume
- 144
- Category
- Article
- ISSN
- 0378-4274
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Our earlier investigation demonstrated that methoxychlor treatment induced hepatic cytochrome P450 2B1/2B2 and 3A proteins in rats and enhanced their respective enzymatic activities. To determine the mechanism of the methoxychlor-mediated induction and whether methoxychlor acts as a frank inducer an
## Abstract We report a comprehensive examination of rat hepatic CYP1A2 and CYP2E1 ontogeny. We compare the data to human data to determine the rat's capacity as a model to identify CYP‐mediated mechanisms underlying age‐dependent differences in susceptibility to toxicity. We evaluated CYP expressi