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Presenilin-1 (PS1) and amyloid precursor protein (APP) mutations present in mouse models of Alzheimer's disease in their response to γ-secretase inhibitors and modulators

✍ Scribed by Lehmann, Stefanie; Bruening, Tanja; Ness, Julia; Czirr, Eva; Bulic, Bruno; Pietrzik, Claus U.; Weggen, Sascha


Book ID
123387537
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
64 KB
Volume
5
Category
Article
ISSN
1552-5260

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To determine whether the presenilin 1 (PS1), presenilin 2 (PS2) and amyloid beta-protein precursor (APP) mutations linked to familial Alzheimer's disease (FAD) increase the extracellular concentration of amyloid beta-protein (A beta) ending at A beta 42(43) in vivo, we performed a blinded comparison