Presence of NADPH-cytochrome P450 reductase in central catecholaminergic neurones
✍ Scribed by Haglund, Lena; Köhler, Christer; Haaparanta, Tapio; Goldstein, Menek; Gustafsson, Jan-Åke
- Book ID
- 109734238
- Publisher
- Nature Publishing Group
- Year
- 1984
- Tongue
- English
- Weight
- 646 KB
- Volume
- 307
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/307259a0
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## Abstract Summary: NADPH‐cytochrome P450 reductase (CPR or POR) is the obligatory electron donor for all microsomal cytochrome P450 (CYP or P450)‐catalyzed monooxygenase reactions. Disruption of the mouse __Cpr__ gene has been reported to cause prenatal developmental defects and embryonic lethali
## Abstract NADPH–cytochrome P450 reductase, an obligatory component of the cytochrome P450 dependent monooxygenase system, was purified to electrophoretic homogeneity from beef liver microsomes. The purification procedure involved the ion exchange chromatography of the detergent‐solubilized micros