## Abstract Summary: NADPH‐cytochrome P450 reductase (CPR or POR) is the obligatory electron donor for all microsomal cytochrome P450 (CYP or P450)‐catalyzed monooxygenase reactions. Disruption of the mouse __Cpr__ gene has been reported to cause prenatal developmental defects and embryonic lethali
Engineering of proteolytically stable NADPH-cytochrome P450 reductase
✍ Scribed by T. A. Bonina; A. A. Gilep; R. W. Estabrook; S. A. Usanov
- Publisher
- Springer
- Year
- 2005
- Tongue
- English
- Weight
- 640 KB
- Volume
- 70
- Category
- Article
- ISSN
- 0006-2979
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract NADPH–cytochrome P450 reductase, an obligatory component of the cytochrome P450 dependent monooxygenase system, was purified to electrophoretic homogeneity from beef liver microsomes. The purification procedure involved the ion exchange chromatography of the detergent‐solubilized micros
NADPH-cytochrome P-450 oxidoreductase (P-450 red) transfers reducing equivalents from NADPH to cytochrome P-450 (P-450) in the monooxygenase system. Detergent solubilized proteins from the membrane fraction of neonatal rat epidermis were purified by 2',5'-ADP-agarose affinity column chromatography.