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Preparation of α,α-difluoromethylene functionalized sulfones

✍ Scribed by Zhen-Yu Yang; Donald J. Burton

Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
978 KB
Volume
3
Category
Article
ISSN
1042-7163

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✦ Synopsis

Sulfination of brorrrodifluoroacetate or acetaitiide 1 with sodiurrr dithionite gives the corresponding sulfinates 2a and 2b, respectively, which upon cuprous bromide catalyzed allylation afford the allylsulfonyldifluoroacetate and acetatnides. Phenyl-or alkylsulfonyldifluoroacetates and acetamides can be readily prepared from reaction of 1 with thiolates, followed by oxidation with hydrogen peroxide.

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