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ChemInform Abstract: Preparation of α-Methylene-γ-butyrolactones with Difluoromethylene Functionalities.

✍ Scribed by H. FUKUDA; T. KITAZUME

Publisher
John Wiley and Sons
Year
2010
Weight
34 KB
Volume
29
Category
Article
ISSN
0931-7597

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✦ Synopsis

Preparation of α-Methylene-γ-butyrolactones with Difluoromethylene Functionalities.

-The key to the preparation of title compounds such as (XII), of interest as pharmaceutical drugs, is the regioselective reduction of the ester group of compound (VI) activated with a difluoromethylene unit to give the diol (VII). -(FUKUDA, H.;

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