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Preparation and reactivity of an α-(difluoromethylene)-γ-lactone

✍ Scribed by Minoru Suda

Publisher
Elsevier Science
Year
1981
Tongue
French
Weight
179 KB
Volume
22
Category
Article
ISSN
0040-4039

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✦ Synopsis

3-(Difluoromethylene)-4,4-dimethyloxolan-2-one, prepared by difluoromethylenation of 4,4-dimethyloxolan-2,3-dione, exhibits marked reactivity toward nucleophilic reagents. a-Methylene-y-lactone structure is found in many naturally occurring terpenes and some of them are known to exhibit biological activities. Encouraged by this nature, a large number of synthetic m,ethods to construct this unique functional moiety have been developed by now. 1) As a part of our

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