## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v
Preparation of the major urinary metabolite of (−)-prostaglandin E2
✍ Scribed by Douglass F. Taber; Peiming Gu
- Book ID
- 108283015
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- French
- Weight
- 265 KB
- Volume
- 65
- Category
- Article
- ISSN
- 0040-4020
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AbstractÐThe enantiomeric prostaglandins, exempli®ed by ent-PGE 2 , are apparently produced in vivo by the nonenzymatic oxidation of arachidonic acid. To assess the physiological activity of ent-PGE 2 , it was necessary to prepare it by total synthesis. The key transformation in this synthesis was t
The synthesis of deuterium-and tritium-labeled analogs of 2,3-dinor-6-keto-prostaglandin F,, and of 6,15-diketo-13,14-dihydro-2,3-dinor-prostaglandin F,, is described. These analogs were used as internal standards in the assay of the corresponding unlabeled metabolites in human urine by stable isoto