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Preparation of ent-Prostaglandin E2

โœ Scribed by Douglass F Taber; Qin Jiang

Book ID
104202851
Publisher
Elsevier Science
Year
2000
Tongue
French
Weight
99 KB
Volume
56
Category
Article
ISSN
0040-4020

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โœฆ Synopsis

AbstractรThe enantiomeric prostaglandins, exempliยฎed by ent-PGE 2 , are apparently produced in vivo by the nonenzymatic oxidation of arachidonic acid. To assess the physiological activity of ent-PGE 2 , it was necessary to prepare it by total synthesis. The key transformation in this synthesis was the equilibration of the kinetically prepared ent-15-E 2t -isoprostane to ent-PGE 2 .

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