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Quantitative analysis of two dinor urinary metabolites of prostaglandin I2

✍ Scribed by Pierre Falardeau; John A. Oates; Alan R. Brash

Book ID
102984472
Publisher
Elsevier Science
Year
1981
Tongue
English
Weight
679 KB
Volume
115
Category
Article
ISSN
0003-2697

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✦ Synopsis

The synthesis of deuterium-and tritium-labeled analogs of 2,3-dinor-6-keto-prostaglandin F,, and of 6,15-diketo-13,14-dihydro-2,3-dinor-prostaglandin F,, is described. These analogs were used as internal standards in the assay of the corresponding unlabeled metabolites in human urine by stable isotope dilution and combined gas chromatography-mass spectrometry. In male subjects the 24-h urinary excretion of the two metabolites was found to be 719 + 264 and 3 14 f I 15 ng, respectively.

The method offers a noninvasive approach to the study of prostaglandin I2 synthesis in man.

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