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Preparation of sodium cromoglycate (intalR) labelled with isotopic hydrogen

✍ Scribed by W J S Lockley; D J Wilkinson

Publisher: John Wiley and Sons
Year: 1984
Tongue: French
Weight: 410 KB
Volume: 21
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580210411

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✦ Synopsis

Procedures for the labelling of the anti-allergic drug, sodium cromoglycate, with both tritium and deuterium are described. by acid catalysed exchange with deuterosulphuric acid. The 2-2H and Z-3H isotopomers were prepared via borodeuteride and borotritide reductions of an 0x0-precursor. Sodium [ 3 , 3 '-3H] cromoglycate was prepared at high specific radioactivity by rhodium(II1) chloride catalysed exchange with high atom X abundance tritiated water.

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