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Preparation of Size Tunable Amphiphilic Poly(amino acid) Nanoparticles

✍ Scribed by Hyungjin Kim; Takami Akagi; Mitsuru Akashi

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
546 KB
Volume
9
Category
Article
ISSN
1616-5187

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✦ Synopsis

Abstract

Size tunable amphiphilic NPs composed of poly(γ‐PGA) and hydrophobic amino acids, such as Phe or Trp, were prepared. To prepare these size‐regulated NPs, γ‐PGA‐g‐Phe or γ‐PGA‐g‐Trp dissolved in DMSO was added to various concentrations of NaCl solution. The γ‐PGA‐Phe and γ‐PGA‐Trp formed monodispersed NPs, and the size of NPs can be easily controlled by NaCl concentration. The different‐sized NPs showed the same structure. The encapsulation of protein into the different‐sized NPs was successfully achieved and the size of protein‐encapsulated γ‐PGA‐Phe NPs was increased when protein was encapsulated.

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