Preparation of poly(methyl methacrylate) microspheres modified with amino acid moieties

✍ Scribed by Kohei Shiraishi; Tsunehisa Ohnishi; Kazuo Sugiyama

• Publisher: John Wiley and Sons
• Year: 1998
• Tongue: English
• Weight: 768 KB
• Volume: 199
• Category: Article
• ISSN: 1022-1352
• DOI: 10.1002/(sici)1521-3935(19980901)199:9<2023::aid-macp2023>3.0.co;2-v

✦ Synopsis

Poly(methy1 methacrylate) microspheres [poly(SerMA-co-MMA), poly(A1aMAm-co-MMA), poly(A1aEMA-co-MMA, and poly(AlaMAmlA1aEMA-co-MMA)] modified with 0-methacryloyl-L-serine (SerMA), N-methacryloyl-L-alanine (AlaMAm) and L-alanine 2-methacryloyloxyethyl ester (AlaEMA) were prepared by the emulsifier-free emulsion copolymerization of methyl methacrylate (MMA) with SerMA, AlaMAm and AlaEMA, respectively, initiated with 2,2'-azobis[2-(2-imidazolin-2-yl)propane] dihydrochloride (ABIP). The series of polymer microspheres showed unimodal distribution of the particle size (290-800 nm) in water. From X-ray photoelectron spectroscopy it was concluded that the amino acid moieties are located on the surface of the particles in all cases. Poly(SerMA-co-MMA) showed the most effective suppression of adsorption of proteins such as albumin (Alb), y-globulin (Glo) and fibrinogen (Fib) among the examined poly(methylmethacry1ate) microspheres