Preparation of optically active 2-(trifluoromethyl)alkan-1-ols by catalytic asymmetric hydrogenation
โ Scribed by Katsuhiko Iseki; Yoshichika Kuroki; Takabumi Nagai; Yoshiro Kobayashi
- Book ID
- 103183232
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 194 KB
- Volume
- 69
- Category
- Article
- ISSN
- 0022-1139
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Asymmetric hydrosilylation of l-arylbutadienes with trichlorosilane in the presence of a chiral ferrocenylphosphine-palladium catalyst gave optically active allylsilanes, (z)-laryl-1-silyl-Z-butenes and their regioisomers.
It is well documented that the d-and l-isomers of 2-amino-l-arylethanols such as epinephrine show a different biological and pharmacological activity,' and the optical isomers have been obtained through the resolution of the racemate' or from optically active precursors by chemical transformation.2