Asymmetric synthesis of 2-amino-1-arylethanols by catalytic asymmetric hydrogenation

✍ Scribed by Tamio Hayashi; Akifumi Katsumura; Mitsuo Konishi; Makoto Kumada

• Book ID: 104244638
• Publisher: Elsevier Science
• Year: 1979
• Tongue: French
• Weight: 249 KB
• Volume: 20
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(01)93523-3

✦ Synopsis

It is well documented that the d-and l-isomers of 2-amino-l-arylethanols such as epinephrine show a different biological and pharmacological activity,' and the optical isomers have been obtained through the resolution of the racemate' or from optically active precursors by chemical transformation.2 To our knowledge, there has been no example of asymmetric synthesis of 2-amino-1-arylethanols by chemical reduction of prochiral ketones3 in spite of great current interest in asymmetric synthesis.