α-Amino acids by catalytic asymmetric hydrogenation
✍ Scribed by B.D. Vineyard; W.S. Knowles; M.J. Sabacky
- Publisher
- Elsevier Science
- Year
- 1983
- Weight
- 546 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0304-5102
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📜 SIMILAR VOLUMES
The Rh-DuPHOS and Rh-BPE catalyzed hydrogenation of IS-substituted ¢x,[~,y,8-unsaturated amino acids establishes two contiguous stereogenic centers simultaneously. Both high regioselectivity and good to excellent enantioselectivity have been demonstrated in this process leading to I~-branched allyl
## Abstract For Abstract see ChemInform Abstract in Full Text.
Copper(salen) complex 1 has been found to catalyse the asymmetric alkylation of enolates derived from a variety of amino acids. There is a clear relationship between the size of the side chain in the substrate and the enantioselectivity of the process, so that the enantioselectivity decreases in the