Simple amino acids (1) can be converted in fair to good yield into hydrazino acids (3) of like configuration by using KOCI instead of NaOCl to promote the Shestakov rearrangement of the intermediate hydantoic acids (2). It was shown fifteen years ago by Karady et al.,' and later by Custafsson,' that
Preparation of optical active aliphaticα-amino acid from fatty acid: synthesis ofl-norvaline andd-norvaline
✍ Scribed by Chao Qian; Ling Gong; Xin Zhi Chen
- Book ID
- 106517764
- Publisher
- Springer Netherlands
- Year
- 2009
- Tongue
- English
- Weight
- 183 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0922-6168
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## Abstract Starting from the enantiomerically pure building block 2 which is readily available from D‐asparagine α,β‐disubstituted β‐amino nitriles and β‐amino acids could be synthesized. After deprotonation of the nitrile α‐position the introduction of substituents was performed by alkylation of