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Practical synthesis of optically active α-hydrazino acids from α-amino acids

✍ Scribed by Joëlle Viret; Jacqueline Gabard; André Collet

Publisher
Elsevier Science
Year
1987
Tongue
French
Weight
290 KB
Volume
43
Category
Article
ISSN
0040-4020

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✦ Synopsis

Simple amino acids (1) can be converted in fair to good yield into hydrazino acids (3) of like configuration by using KOCI instead of NaOCl to promote the Shestakov rearrangement of the intermediate hydantoic acids (2). It was shown fifteen years ago by Karady et al.,' and later by Custafsson,' that simple amino acids (1) can

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Convenient synthesis of optically active
Convenient synthesis of optically active α-hydroxyphosphinic acids
✍ Juexiao Cai; Zhenghong Zhou; Guofeng Zhao; Chuchi Tang 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 93 KB

## Abstract The reaction of O‐menthyl phenylphosphonite **__1__** with aromatic aldehydes in the presence of Me~3~SiCl provided the O‐menthyl α‐hydroxyphosphinates **__2__**. Acidic hydrolysis of **__2__** gave the corresponding α‐hydroxyphosphinic acids **__3__**. The (+)‐enantiomer of **__3a__**