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Preparation of NG-monoethyl-l-arginine

✍ Scribed by Yung-Bong Cho; George Furst; Woon Ki Paik

Publisher
Elsevier Science
Year
1984
Tongue
English
Weight
412 KB
Volume
139
Category
Article
ISSN
0003-2697

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✦ Synopsis

NG-Monoethyl-L-arginine, a putative in vivo product after administration of the potent hepatocarcinogen L-ethionine to rats, has been chemically synthesized by coupling N-ethyl, S- methylthiopseudouronium iodide with alpha-amino-blocked L-ornithine. The structure of the compound as NG-monoethyl-L-arginine was confirmed by 13C NMR. Its elution time on an automatic amino acid analyzer, Rf values using thin-layer chromatography, and isoelectric point have been compared with those of NG-monomethyl-L-arginine.

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