A convenient synthesis of NG-mono[14C-methyl]-L-arginine
✍ Scribed by M. Abou-Gharbia; W. K. Paik; D. Swern
- Publisher
- John Wiley and Sons
- Year
- 1981
- Tongue
- French
- Weight
- 144 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0022-2135
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
N^G^‐Mono[^14^C‐methyl]‐L‐arginine was prepared in a two‐step synthesis. N,S‐dimethylthiopseudouronium iodide [methyl‐^14^C] was prepared in excellent yield and afforded the labelled amino acid on coupling with L‐ornithine.
📜 SIMILAR VOLUMES
NG-Monomethylagmatine, a decarboxylation product of NG-monomethyl-L-arginine, has been synthesized by reacting putrescine with N,S-dimethylthiopseudouronium iodide. The structural identity of the product was confirmed by proton NMR and mass spectroscopy, and its properties were determined on thin-la
## Abstract A convenient synthesis with analytical monitoring of ^14^C‐cotinine is reported. ^14^C‐Nicotine was converted into ^14^C‐dibromocotinine hydrobromide perbromide. Debromination, achieved by using Zn dust/acetic acid, resulted in high yields (71%) of ^14^C‐cotinine.
## Abstract A simple and convenient laboratory procedure is described by which hordenine (III), labelled at the carbon residing on the benzene ring, can be synthesized by decarboxylation of 3‐ [^14^C]‐tyrosine (1) and subsequent reductive methylation of the resulting tyramine (II).