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Preparation of deuterium labelled α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA)

✍ Scribed by Jørn Lauridsen; Tage Honoré

Publisher: John Wiley and Sons
Year: 1981
Tongue: French
Weight: 209 KB
Volume: 18
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580181012

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✦ Synopsis

Abstract

The preparation of α‐amino‐3‐hydroxy‐5‐methylisoxazole‐4‐propionic acid (AMPA) with deuterium α to the carboxylic acid group (2) and in the exocyclic methyl group (5), respectively, are described. The deuterium labelled AMPA (2) was synthesized by hydrolysis and decarboxylation of the corresponding di‐ester (1), whereas the deuterium labelled AMPA (5) was prepared via a catalytic deuteration of the bromoderivative (3).

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