𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Preparation of deuterated toluidines and xylidines

✍ Scribed by C. G. B. Frischkorn; H. Kohler; B. Rose; D. Unterlugauer; H. M. Conrad

Publisher
John Wiley and Sons
Year
1978
Tongue
French
Weight
232 KB
Volume
14
Category
Article
ISSN
0022-2135

No coin nor oath required. For personal study only.

✦ Synopsis

Deuteration in definite positions of the aromatic ring system or in the side chain of different methyl anilines is achieved in D20 under different conditions: at 150Β°C and pH 3 deuteration occurs in ortho/para positions; whereas at 250Β°C and pH 3 a total deuteration of the aromatic system takes place (overall deuteration 82-99%). Perdeuteration (81-99% in the aromatic ring, 60-99% in the side chain) is obtained in high acidic medium (pH L 1 ) and at 250Β°C. The yield of the deuterated methyl anilines is generally high (40-100%) so that this reaction is a more attractive route for preparing methyl anilines and their derivatives than the conventional ways of synthesis. By using T20 instead of D20 it should be possible to prepare the appropriate tritium-labelled compounds.

πŸ“œ SIMILAR VOLUMES

Convenient preparation of deuterated ura
Convenient preparation of deuterated uracils and dihydrouracils
✍ Richard K. Hill; N. Dale Ledford; Louis A. Renbaum πŸ“‚ Article πŸ“… 1985 πŸ› John Wiley and Sons 🌐 French βš– 196 KB

The reaction of with DC1 affords [5,6-2H21uracil. Reaction of the and G -i s o m e r s of [2,3-2H2]succinamide with lead tetraacetate leads to the cis and trans isomers of [ 5, 6-2H2] 5,6-dihydrourac i 1.

Preparation of selectively deuterated sa
Preparation of selectively deuterated salen ligands
✍ Dennis G. Brown; Chit Srivanavit πŸ“‚ Article πŸ“… 1979 πŸ› John Wiley and Sons 🌐 French βš– 206 KB

## Abstract A number of selectively deuterated derivatives of the common ligand N,N′‐ethylenebis(salicylidenimine), salen, have been prepared. The synthesis involves preparation of selectively deuterated salicylaldehydes. Procedures necessary to carry out these syntheses are described below.