โ Scribed by Xiongwei Li; Jing Xiao; Xianmo Deng; Xiadyi Li; Hongli Wang; Wenxiang Jia; Wenbing Zhang; Li Men; Yan Yang; Zhenxi Zheng
No coin nor oath required. For personal study only.
Biodegradable polymer poly-D,L-lactide-polyethylene glycol (PLA-PEG) was synthesized with stannous octoate (SnOc 2 ) as catalyst by a cationic ring-opening polymerization. The molecular weight of PLA-PEG is the highest at a content of 0.1% SnOc 2 . The PLA-PEG microspheres carrying protein were prepared by a solvent evaporation composite emulsion technique with a narrow size range (1-2 mm). The sizes of PLA-PEG microspheres increased with the increase of the molecular weight of PLA-PEG. The PEG in PLA-PEG (10%) significantly improved the size control of the microspheres of the PLA family as a drug carrier matrix. Polyvinyl alcohol (PVA) aqueous solution was used as dispersion medium for microsphere preparation. The concentration of the PVA solution can affect the size of the PLA-PEG microspheres. The differential scanning calorimetry data showed that the PLA-PEG microspheres can efficiently encapsulate the protein and that the crystalline of the microspheres carrying protein was lower than that of the nonprotein-loading microspheres. The amount of protein carried in the PLA-PEG microspheres was related to the nature of the protein itself.
๐ SIMILAR VOLUMES
For the purpose of extending the size range of polymer seed particles used in "dynamic swelling method" (DSM), first it was verified theoretically that the submicron-sized polymer particles produced by emulsion polymerization can also absorb a large amount of monomer by DSM in both equilibrium and k