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Preparation of amides from acids and resin bound azides: Suppression of intramolecular lactam formation

โœ Scribed by Zhilian Tang; Jeffrey C. Pelletier

Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
210 KB
Volume
39
Category
Article
ISSN
0040-4039

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โœฆ Synopsis

A new method for the formation of amides on solid phase has been developed. The procedure involves the reaction between activated acids in solution and resin bound iminophosphoranes generated from the corresponding azides and tributylphosphine. The method is particularly attractive when starting from 8 azido acids since amides can form without internal cyclization to the lactam.

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