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Preparation of (2R,3S)-(−)- and (2S,3R)-(+)-2,3-epoxy-2-methylbutanoic acids and some of their esters

✍ Scribed by J Martín Torres-Valencia; Carlos M Cerda-García-Rojas; Pedro Joseph-Nathan


Book ID
108036307
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
326 KB
Volume
6
Category
Article
ISSN
0957-4166

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✍ Philippe Karoyan; Gérard Chassaing 📂 Article 📅 1997 🏛 Elsevier Science 🌐 English ⚖ 547 KB

The synthesis of 3-prolinomethionine can be easily achieved in a diastereoselective and enantioselective way via zinc-enolate cyclisation. After transmetallation by CuCN.2LiCI, the zinc--copper derivative was reacted with S-methyl methanesulfonothioate leading in a "one-pot" procedure, to N-(0t-meth