Convenient route for the preparation of C2-symmetric (+)-(2R,3R)- and (−)-(2S,3S)-2,3-diphenylaziridine
✍ Scribed by Adelfo Reyes; Eusebio Juaristi
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 114 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0899-0042
- DOI
- 10.1002/chir.16
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2-Ethoxy-1-methyl-5-pymlidinone (1) was reacted with ethyl [3,4-'3C2]acetoacetate (2) in the presence of T i c 4 to give ethyl [3,4-13C2]-2-( 1'-methyl-5'oxo-2'-pyrrolidinyl)-3-oxobutanoate (3) in 85% yield. Decarboethoxylation of ethyl [3,4-13C2]-2-( l'-methyl-5'-oxo-2'-pyrrolidiny1)-3-oxobutanoate
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