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Preparation of 2H- and 13C-labelled precursors of 2-hydroxy-1,3-butadiene

✍ Scribed by František Tureček

Publisher
John Wiley and Sons
Year
1987
Tongue
French
Weight
373 KB
Volume
24
Category
Article
ISSN
0022-2135

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✦ Synopsis

Czechoslovakia 2-=Vinylbicyclo L2.2. lJhept-5--2-0ls, specif i d l y labelled w i t h % at C-3 and in the vinyl group wre p m f m bicyclof2~.2.l]hept-5-en-2-ane in several steps. 13 13 [4-C]oct-l-en-3was prepared in five steps fran These curpow& serve as precursors for the preparatim of c02. specifically labelled neutral and i d z e d 2-hydroJry-l,3-butadimes.

%-labelled.

2-Hydroxyl,3-butadiene 111 is an unstable err01 that shcrws a peculiar loss of a methyl grcxlp follmirq electrcn-impact ionization 121.

explain the mechanism of t h i s mss spectral fragmentation ne needed to idmtify via specific ? i and 13C labelling the hydrogen and carbon atans in the methyl eliminated. he [cH~=cH-c(cH)-cH~]+. ion can be generated by the retm-D i e l s -A l d e r fragmentation of 2~inylbicycl0[2.2.l]hept-5-en-2-01 , 1 , [ 31, ~n order t a 0362-4803/87/0lo(n3-10$05.00 @ 1987 by John Wiley & Sons, Ltd.

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