𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Preparation of 2,4-diamino-6-(diallylamino)-s-triazine-2,4-14c and its hypotensive metabolite, 2,4-diamino-6-(diallylamino)-s-triazine-2,4-14c 3-oxide

✍ Scribed by Richard C. Thomas

Publisher
John Wiley and Sons
Year
1978
Tongue
French
Weight
202 KB
Volume
14
Category
Article
ISSN
0022-2135

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

2,4‐Diamino‐6‐(diallylamino)‐s‐triazine‐2,4‐^14^C was prepared from K^14^CN in a four step sequence of reactions. The product was obtained in 26% yield at a specific activity of 1.01 mCi per mM. This product was converted to the hypotensive agent, 2,4‐diamino‐6‐(diallylamino)‐s‐triazine‐2,4‐^14^C 3‐oxide in 37% yield by oxidation with m‐chloroperbenzoic acid.

📜 SIMILAR VOLUMES

Synthesis of the 5-nitrofuran 2,4-diacet
Synthesis of the 5-nitrofuran 2,4-diacetylamino-6-(5-nitro-2-furyl)-1,3,5-triazine-6-14C
✍ Dennis R. Doose; Betty-Ann Hoener 📂 Article 📅 1983 🏛 John Wiley and Sons 🌐 French ⚖ 213 KB

The s y n t h e s i s of t h e 5 -n i t r o f u r a n 2,4-diacetylamino-6-(5-nitro-2-furyl)- is d e s c r i b e d . F u r y l l i t h i u m i n e t h e r i s c a r b o x y l a t e d w i t h radio-carbon d i o x i d e g e n e r a t e d from Ba14COj. The furoic-carbonyl-14C a c i d is t h e n e s t e

The ionization constants of 2-substitute
The ionization constants of 2-substituted 4,6-diamino-s-triazines: The applicability to the hammett and taft equations
✍ Tatsuo Tashiro 📂 Article 📅 2002 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 147 KB

The ionization (or basicity) constants (pK b ) were determined for many 2-substituted 4,6-diamino-s-triazines (I) by means of the electrometric titration. I includes 2-alkoxy or aryloxy-(Ia), 2-alkyl-or 2-aryl-(Ib), and 2-alkylamino-or 2-arylamino-4,6-diamino-s-triazines (Ic). For the series with th

One step conversion of glutarimide-2,6-1
One step conversion of glutarimide-2,6-14C to pentachloropyridine-2,6-14C and its subsequent use in the synthesis of 2-octyl (4-amino-3,5-dichloro-6-fluoro-2-pyridinyloxy-2,6-14C)acetate
✍ L. H. McKendry 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 French ⚖ 208 KB 👁 1 views

## Abstract A convenient method of preparing 2‐octyl (4‐amino‐3,5‐dichloro‐6‐fluoro‐2‐pyridinyloxy‐2,6‐^14^C)acetate from glutarimide‐2,6‐^14^C is described. The process includes a novel one‐step conversion of glutarimide‐2,6‐^14^C to pentachloropyridine‐2,6‐^14^C.

Synthesis of 14C-labelled (S)-(+)-6-(2-c
Synthesis of 14C-labelled (S)-(+)-6-(2-chlorophenyl)-3-cyclopropanecarbonyl-8,11- dimethyl-2,3,4,5-tetrahydro-8H-pyrido[4′,3′:4,5]thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine (14C-E6123)
✍ Shuhei Miyazawa; Kazuo Okano; Kazutomi Kusano; Kyoichi Tadano; Shigeru Tanaka; T 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 French ⚖ 197 KB 👁 1 views

## Abstract ^14^C‐Labelled (S)‐(+)‐6‐(2‐chlorophenyl)‐3‐cyclopropanecarbonyl‐8,11‐dimethyl‐2,3,4,5‐ tetrahydro‐8H‐pyrido[4′,3′:4,5]thieno[3,2‐f][1,2,4]triazolo[4,3‐a][1,4] diazepine (^14^C‐E6123), a platelet activating factor receptor antagonist for studying the pharmacokinetic profile of E6123, wa