One step conversion of glutarimide-2,6-14C to pentachloropyridine-2,6-14C and its subsequent use in the synthesis of 2-octyl (4-amino-3,5-dichloro-6-fluoro-2-pyridinyloxy-2,6-14C)acetate
✍ Scribed by L. H. McKendry
- Publisher
- John Wiley and Sons
- Year
- 1990
- Tongue
- French
- Weight
- 208 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0022-2135
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
A convenient method of preparing 2‐octyl (4‐amino‐3,5‐dichloro‐6‐fluoro‐2‐pyridinyloxy‐2,6‐^14^C)acetate from glutarimide‐2,6‐^14^C is described. The process includes a novel one‐step conversion of glutarimide‐2,6‐^14^C to pentachloropyridine‐2,6‐^14^C.
📜 SIMILAR VOLUMES
## Abstract 2‐Amino‐3,5‐dihydro‐7‐(3‐thienylmethyl)‐[6‐^14^C]‐4H‐pyrrolo [3,2‐d]pyrimidin‐4‐one monohydrochloride ([^14^C]Cl‐1000), a potent purine nucleoside phosphorylase inhibitor, was made in six steps from potassium [^14^C]cyanide. A key step was the reduction of a nitro and a nitrile group wi
## Isopropyl -8,9-dimethoxy-benzofurano[2~3-bJfuro[2,3-hJ[ll [ 1 1 -"C]benzopyran-6-one(IVb) and 3-(2-hydroxy-4,5-~~methoxyphenyl)-4-hydroxy-5'-isopropylfurano[2',3':7,8][2-C]coumarin(Vb) were prepared from isorotenone(1b) for use in metabolic and other studies. Deoxybenzoin derivat've(IIb), obtai
## Abstract A group of radioactive 1,4‐benzodiazepine derivatives have been synthesized from glycine‐1‐^14^C. The subject compounds are labeled with carbon‐14 in the 2‐position of the 1,4‐benzodiazepine ring system.
The compound 6-chloro-2,3,4,5-tetrahydroi~-methyl-l &3-t#nzazepine (SK&F 86466) was prepared in phenyl-U-C and phenyl-C , labeled forms in a six step sequence beginning with the appropriately labeled benzenes. In addition, the N-desmeJhyl analog of the carbon-1 4 labeled isotopomer and the N-methyl-