A 1 6 . 7 m C i sample of 99+% r a d i o c h e m i c a l l y p u r e 2-chloro-6-(2-f uranylmethoxy ) -4 -t r i c h l o r o m e t h y l p y r idine-2 , 6 -1 4 C w i t h a s p e c i f i c a c t i v i t y of 13.
Preparation of 2,3,5,6-tetrachloropyridine-2,6-14C
✍ Scribed by L. H. McKendry
- Publisher
- John Wiley and Sons
- Year
- 1981
- Tongue
- French
- Weight
- 390 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0022-2135
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
An 88.6% yield of 2,3,5,6‐tetrachloropyridine‐2,6‐^14^C (8.99 mCi, 14.5 mCi/mmole) was obtained via chlorination of 2,6‐dichloropyridine‐2,6‐^14^C.
📜 SIMILAR VOLUMES
## Abstract Biphenyl‐2,2′,3,3′,5,5′,6,6′‐^2^H~8~ was prepared from biphenyl‐d~10~. Initial bromination of biphenyl‐d~10~ followed by hydrogenolysis of the 4,4′‐dibromobiphenyl‐d~8~ with lithium aluminum hydride gave the desired product in 40% overall yield.
6-14C]Nitrendipine synthesis started from barium[14]carbonate, which was converted to [ 1-14C] acetyl chloride. The acid chloride was condensed with Meldrum's acid (2,2-dimethyl-1,3-dioxane-4,6-dione). The resulting intermediate was treated with boiling methanol to give methyl [ 3-14C]acetoacetate.
## Abstract A 20.4 mCi sample of 99% radiochemically pure 3,6‐dichloropicolinic acid‐2,6‐^14^C with a specific activity of 11.6 mCi/ mmole was synthesized __via__ a five step process from glutarimide‐ 2, 6‐ ^14^C.
2, 6-Dichloropyridine-2, 6-14C with a specific activity of 18.79 mCi/mmole was prepared in a 78% yield the reaction of glutarimide-2,6-14C and PC1 . presents a marked improvement over prevjously reported yields y & this process.
## Abstract Modification of the traditional. Gomberg reaction conditions provides a simple, economical. route to 2‐chlorobiphenyl‐1′,2′,3′,4′,5′,6′‐^14^__C__~6~ __(I). The reaction of benzene‐U‐__^14^__C__~6~ __with an excess of the diasonium salt from__ 2__‐chloroaniline produces__ ^14^__C‐labelle