## Abstract A 20.4 mCi sample of 99% radiochemically pure 3,6‐dichloropicolinic acid‐2,6‐^14^C with a specific activity of 11.6 mCi/ mmole was synthesized __via__ a five step process from glutarimide‐ 2, 6‐ ^14^C.
2, 6-dichloropyridine-2, 6-14C
✍ Scribed by Lennon H. McKendry; W. W. Muelder
- Publisher
- John Wiley and Sons
- Year
- 1978
- Tongue
- French
- Weight
- 252 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0022-2135
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✦ Synopsis
2, 6-Dichloropyridine-2, 6-14C with a specific activity of 18.79 mCi/mmole was prepared in a 78% yield the reaction of glutarimide-2,6-14C and PC1 . presents a marked improvement over prevjously reported yields y & this process.
📜 SIMILAR VOLUMES
## Abstract 6‐n‐Propyl‐2‐thiouracil‐6−^14^C was prepared from sodium butyrate‐1−^14^C, with a radiochemical yield of 34%. Butyryl chloride‐1−^14^C was prepared from butyric acid‐1−^14^C and condensed with sodio ethylacetoacetate to yield ethyl β‐oxohexanoate‐β−^14^C. The β‐keto ester was condensed
## Abstract An 88.6% yield of 2,3,5,6‐tetrachloropyridine‐2,6‐^14^C (8.99 mCi, 14.5 mCi/mmole) was obtained __via__ chlorination of 2,6‐dichloropyridine‐2,6‐^14^C.
6-14C]Nitrendipine synthesis started from barium[14]carbonate, which was converted to [ 1-14C] acetyl chloride. The acid chloride was condensed with Meldrum's acid (2,2-dimethyl-1,3-dioxane-4,6-dione). The resulting intermediate was treated with boiling methanol to give methyl [ 3-14C]acetoacetate.
A 1 6 . 7 m C i sample of 99+% r a d i o c h e m i c a l l y p u r e 2-chloro-6-(2-f uranylmethoxy ) -4 -t r i c h l o r o m e t h y l p y r idine-2 , 6 -1 4 C w i t h a s p e c i f i c a c t i v i t y of 13.
Two o f t h e m i n o r m e t a b o l i t e s o f t h e a n t i t h y r o i d d r u g 6 -p r o p y l -2t h i o u r a c i l ( I ) have been i s o l a t e d f r o m r a t u r i n e i d e n t i f i e d as S-methyl-6 -p r o p y l -2 -t h i o u r a c i l