## Abstract In a first step, Δ1‐trans‐octenoic‐3‐^14^C acid was prepared by a Grignard reaction with BaCO~3~‐^14^C and 1‐bromo‐pentane, followed by reduction of the obtained hexanoic‐1‐^14^C acid to hexanal‐1‐^14^C via the n‐hexanol‐1‐^14^C. The produced hexanal‐1‐^14^C, by condensing with malonic
Preparation of [2-14C]-2-(p-chlorophenoxy)-2-methylpropionic acid and its ethyl ester, [14C] clofibrate
✍ Scribed by E. Ferdinandi
- Publisher
- John Wiley and Sons
- Year
- 1975
- Tongue
- French
- Weight
- 108 KB
- Volume
- 11
- Category
- Article
- ISSN
- 0022-2135
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📜 SIMILAR VOLUMES
## Abstract A relatively simple route to 2‐substituted adamantane derivatives labelled with ^14^C at the 2‐position in the adamantane skeleton was developed. The approach used (Figure I) involved ring expansion of adamantanone by labelled diazomethane, conversion of the resulting 4‐homoadamantanone
## Abstract The pyrolysis of citric acid‐1, 5‐^14^C~2~ under controlled conditions and subsequent hydrolysis of the anhydride initially produced yields principally 2‐methylenebutanedioic acid‐4‐^14^C (citaconic acid‐^14^C), together with a minor amount of cis‐2‐methylbutenedioic acid‐4‐^14^C (citra
A high-yield, relatively simple synthetic route leading to incorporation of l'C into the secondary position of the adamantane nucleus is described. The synthesis was achieved by the sequence shown in Figure 2. The key steps involved the introduction of a I4C label by diazome1hane-14C ring expansion
Specifically labelled phenylacetic acid and mandelic acid derivatives, metabolites of L-Dopa, have been synthesized via the intermediary labelled benzyl alcohols, which were prepared by reduction of the methyl esters of the appropriate benzoic acids. The benzyl alcohols have been converted to the co