Nucleophilic substitution of vinylic iodide of methyl 2-(1-hydroxyalkyl)-3-iodo prop-2-enoates 8 in the presence of magnesium dialkyl cuprates generated in situ provided a stereoselective methodology for the synthesis of infrequent b-substituted Baylis-Hillman products.
Preparation of 2-(1-Hydroxyalkyl)acrylic Esters; Simple Three-Step Synthesis of Mikanecic Acid
✍ Scribed by Prof. H. M. R. Hoffmann; Dr. Jürgen Rabe
- Publisher
- John Wiley and Sons
- Year
- 1983
- Tongue
- English
- Weight
- 231 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0044-8249
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