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A Stereoselective Synthesis of α-(1-Hydroxyalkyl)-β-Substituted Acrylic Acid Esters

✍ Scribed by Taı̈cir Ben Ayed; Jean Villiéras; Hassen Amri

Publisher
Elsevier Science
Year
2000
Tongue
French
Weight
106 KB
Volume
56
Category
Article
ISSN
0040-4020

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✦ Synopsis

Nucleophilic substitution of vinylic iodide of methyl 2-(1-hydroxyalkyl)-3-iodo prop-2-enoates 8 in the presence of magnesium dialkyl cuprates generated in situ provided a stereoselective methodology for the synthesis of infrequent b-substituted Baylis-Hillman products.

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