𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Preparation of 18F-β-D-glucosyl fluoride

✍ Scribed by Alberta E. Lemire; Mary F. Reed

Publisher
John Wiley and Sons
Year
1978
Tongue
French
Weight
184 KB
Volume
15
Category
Article
ISSN
0022-2135

No coin nor oath required. For personal study only.

✦ Synopsis

A rapid procedure for the synthesis of B-D-glucosyl fluoride labelled with the short-lived, positron-emitting radionuclide, 18F, is described. Accelerator produced 18F as Ag18F is reacted with tetra-0-acetyl-a-D-glucoayl bromide, and the product is hydrolyzed with NaOMe producing 18F-6-D-glucooyl fluoride with a radiochemical yield of 15%, based on the activity of the initial reaction mixture corrected for decay, and a purity of about 87%. TLC gave approximately 200 pCi of product with a specific activity of at least 4.4 pcifmg.

Purification by

This glucose analog is of interest as a metabolic tracer and as a potential tumor localizing agent.

📜 SIMILAR VOLUMES

A new synthesis of 2-deoxy-2-[18f]fluoro
A new synthesis of 2-deoxy-2-[18f]fluoro-D-galactose using [18f]fluoride ion
✍ Terushi Haradahira; Minoru Maeda; Yasunobu Kai; Masaharu Kojima 📂 Article 📅 1988 🏛 John Wiley and Sons 🌐 French ⚖ 357 KB 👁 1 views

A nucleophilic radiofluorination of methyl 3,4-0-isopropylidene-2-0-(trif luoromethanesulfonyl) -6-O-trityl-/3-D-talopyranoside (1) with aninopolyether Hydrolysis of 2 with 6N HCl followed by passage through an ion retardation resin column and a neutral alumina column gave 2-deoxy-2-[18F1 f luoro-

Alternative synthesis of no-carrier-adde
Alternative synthesis of no-carrier-added 2-deoxy-2-[18F]fluoro-D-glucose using [18F] fluoride ion
✍ Terushi Haradahira; Minoru Maeda; Masaharu Kojima 📂 Article 📅 1988 🏛 John Wiley and Sons 🌐 French ⚖ 424 KB

Two alternative routes to no-carrier-added synthesis of 2-deoxy-2-[ "F] f luoro-D-glucose (2-18FDG) involving nucleophilic displacements of methyl 3-0-benzyl-4,6-0-benzylidene-2-O-(trifluoromethanesulfonyl~-~-D-mannopyranoside (1) and l,6-anhydro-3,4-di-0-benzyl-2-O-(trifluoromethanesulfonyl)-~-D-ma

Synthesis of 2-deoxy-2-[18F]-fluoro-β-ma
Synthesis of 2-deoxy-2-[18F]-fluoro-β-mannosyl [18F]-fluoride as a potential imaging probe for Glycosidases
✍ John D. McCarter; Michael J. Adam; Stephen G. Withers 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 French ⚖ 221 KB

## Abstract The mechanisms‐based glycosidase inhibitor 2‐deoxy‐2‐[^18^F]‐fluoro‐β‐mannosyl [^18^F]‐fluoride was synthesized and its covalent binding to __Agrobacterium__ β‐glucosidase was demonstrated __in vitro__.

Synthesis of 3′-deoxy-3′-[18F]fluoro-1-β
Synthesis of 3′-deoxy-3′-[18F]fluoro-1-β-D-xylofuranosyluracil ([18F]-FMXU) for PET
✍ M. M. Alauddin; J. Balatoni; J. Gelovani 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 French ⚖ 201 KB 👁 1 views

The synthesis of a pyrimidine analog, 3 0 -deoxy-3 0 -[ 18 F]-fluoro-1-b-d-xylofuranosyluracil ([ 18 F]-FMXU) is reported. 5-Methyluridine 1 was converted to its dimethoxytrityl derivatives 2 and 3 as a mixture. After separation the 2 0 , 5 0 -di-methoxytrityluridine 2 was converted to its 3 0 -trif