✦ LIBER ✦

Preparation of [14C]Musk Xylol

✍ Scribed by Dr. Anita H. Lewin; Usha Ramesh

Publisher: John Wiley and Sons
Year: 1995
Tongue: French
Weight: 200 KB
Volume: 36
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580360606

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Carbonation of the aryl lithium obtained from 5‐t‐butyl‐3‐iodotoluene with carbon‐14 labeled carbon dioxide, followed by reduction gave [ArCH~3~‐^14^C]‐5‐t‐butyl‐m‐xylene. Nitration of this material gave [ArCH~3~‐^14^C]‐5‐t‐butyl‐2,4,6‐ trinitro‐m‐xylene, known as Musk Xylol. The overall yield was 32% and the product had specific activity 19.8 mCi/mmol (66 mCi/mg) and was > 99% pure.

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