✦ LIBER ✦

Preparation of [14C]Acetamidino-insulin

✍ Scribed by Mitsuyoshi Matsuo; Hirose Yamauchi; Toshiro Ooyama; Hajime Orimo

Publisher: John Wiley and Sons
Year: 1980
Tongue: French
Weight: 257 KB
Volume: 17
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580170512

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

[^14^C]Acetamidino‐insulin was synthesized by acetamidination of insulin with methyl [^14^C]acetimidate hydrochloride. The acetamidino‐insulin contains two main components, which can be separated by DEAE‐cellulose column chromatography. They correspond to glycine^A‐1^ ‐ Phenylalanine^B‐1^ ‐ N^ε^ ‐ lysine^B‐29^ ‐ [^14^C]acetamidino‐insulin and glycine^A‐1^ ‐ N^ε^ ‐ lysine^B‐29^ ‐ [^14^C]acetamidino‐insulin. These immunological and biological activity was compared with that of native insulin.

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