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Preparation of 14C-3-hydroxyproline from 14C-proline by Peroxidation

✍ Scribed by Sengoda G. Ramaswamy

Publisher: John Wiley and Sons
Year: 1983
Tongue: French
Weight: 296 KB
Volume: 20
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580200210

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✦ Synopsis

Abstract

Conditions are described for the treatment of proline with hydrogen peroxide, ascorbic acid, and ferrous ions to produce 3‐hydroxyproline in 5–6% yield. Several reaction products are formed, but they can be separated chromatographically to yield pure trans‐3‐hydroxyproline. Synthesis of the radioactive amino acid from ^14^C‐L‐proline yields the pure isomer with specific activity identical to that of the starting proline. Identity of the desired product was established by chromatography, electrophoresis, and mass spectrum.

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