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Preparation of 1,2-dimethoxy-4-(bis-diethylaminoethyl-[14C]-amino)-5-bromobenzene

✍ Scribed by Theodore S. T. Wang; Rashid A Fawwaz; Ronald H. van Heertum

Publisher: John Wiley and Sons
Year: 1993
Tongue: French
Weight: 224 KB
Volume: 33
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580331103

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✦ Synopsis

Abstract

1,2‐Dimethoxy‐4‐(bis‐diethylaminoethyl‐[^14^C]‐amino)‐5‐bromobenzene (III) was synthesized for in vivo pharmacokinetic and pharmacodynamic evaluation. The synthesis of (III) was easily obtained by the direct alkylation of 1,2‐dimethoxy‐5‐bromo‐aniline with beta‐diethylaminoethyl chloride‐ethylene‐[^14^C], using CH~3~MgCl as the proton abstractor. Compound III was obtained with a 22.3% yield. The specific activity was 2.2mCi/mmol, with a radiochemical purity of >99%.

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