## Abstract 1,2‐Dimethoxy‐4‐(bis‐diethylaminoethyl‐[^14^C]‐amino)‐5‐bromobenzene (III) was synthesized for __in vivo__ pharmacokinetic and pharmacodynamic evaluation. The synthesis of (III) was easily obtained by the direct alkylation of 1,2‐dimethoxy‐5‐bromo‐aniline with beta‐diethylaminoethyl chl
[4+2] Cycloaddition reaction of bis (trichloroethyl) azodicarboxylate and glycals: preparation of a C1-C1 2-amino disaccharide
✍ Scribed by Yves Leblanc; Brian J. Fitzsimmons
- Publisher
- Elsevier Science
- Year
- 1989
- Tongue
- French
- Weight
- 226 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0040-4039
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Various derivatives of the heterocyclic system 1,12,12a,12b-tetrahydrobis-1,2,4-triazolo[4,3-a:3 0 ,4 0 -c]quinoxaline of pharmaceutical interest have been obtained by double site-and regio-selective 1,3-dipolar cycloaddition of arylnitrilimines to quinoxalines. No evidence for the formation of mono
## Abstract For Abstract see ChemInform Abstract in Full Text.
The novel and versatile cyanomethyl 2amino-4-methylthiazolyl ketone (5) was prepared by treatment of bromomethyl 2-amino-4-methyl thiazolyl ketone (4) with potassium cyanide. Reaction of 5 with heterocyclic diazonium salts 6a,b and 10 afforded the corresponding hydrazones 7a,b and 11, respectively.