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Bis-1,2,4-triazolo[4,3-a:3′,4′-c]quinoxalines of pharmaceutical interest from 1,3-dipolar cycloaddition

✍ Scribed by Antonino Lauria; Annalisa Guarcello; Gaetano Dattolo; Anna Maria Almerico

Publisher: Elsevier Science
Year: 2008
Tongue: French
Weight: 111 KB
Volume: 49
Category: Article
ISSN: 0040-4039
DOI: 10.1016/j.tetlet.2008.01.047

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✦ Synopsis

Various derivatives of the heterocyclic system 1,12,12a,12b-tetrahydrobis-1,2,4-triazolo[4,3-a:3 0 ,4 0 -c]quinoxaline of pharmaceutical interest have been obtained by double site-and regio-selective 1,3-dipolar cycloaddition of arylnitrilimines to quinoxalines. No evidence for the formation of mono-adducts was obtained, at variance with literature reports. Specific studies to establish the exact stereochemistry of the bis-cycloadducts were undertaken.

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