PREPARATION OF 11-HYDROXYMETHYL-2, 3-NAPHTHO-18-CROWN-6 AND ITS CONVERSION INTO A HIGHLY LIPOPHILIC CROWN CARBOXYLIC ACID
โ Scribed by Czech, Bronislaw; Czech, Anna; Bartsch, Richard A.
- Book ID
- 121205459
- Publisher
- Taylor and Francis Group
- Year
- 1983
- Tongue
- English
- Weight
- 418 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0030-4948
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## Abstract Flecainide, an antiarrythmic agent, and its analogs were resolved on a high performance liquid chromatographic chiral stationary phase (CSP) based on (+)โ(18โcrownโ6)โ2,3,11,12โtetracarboxylic acid with the use of a mobile phase consisting of methanolโacetonitrileโtrifluoroacetic acidโt
A crown ether-based chiral stationary phase (CSP) without extra aminopropyl groups on the surface of silica gel was newly prepared by bonding (+)-(18-crown-6)-2,3,11,12-tetracarboxylic acid to silica gel. The new CSP was applied to the resolution of various racemic alpha-amino acids, amines, and ami